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Within a the latest review, we reported the identification as well as the characterization of a fresh atypical opioid receptor with unique damaging regulatory Homes to opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a broad-spectrum scavenger for